Welcome to HistoCheck - an HLA Sequence Interpreter

References<<< Databases


1.Elsner HA, Blasczyk R. Sequence similarity matching: proposal of a structure-based rating system for bone marrow transplantation. Eur J Immunogenet 2002; 29: 229-236. (PDF)

2.Elsner HA, DeLuca D, Strub J,Blasczyk R. HistoCheck: rating of HLA class I and II mismatches by an internet-based software tool. Bone Marrow Transplant. 2004; 33: 165-169. (PDF)

Shared T-Cell Epitope Algorithms for HLA-DPB1

1.Fleischhauer K, Shaw BE, Gooley T, et al. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study. Lancet Oncology (2012); 13:366-74 Blood. PubMed

2.Crocchiolo R, Zino E, Vago L, Oneto R, Bruno B, Pollichieni S, Sacchi N, Sormani MP, Marcon J, Lamparelli T, Fanin R, Garbarino L, Miotti V, Bandini G, Bosi A, Ciceri F, Bacigalupo A, Fleischhauer K; Gruppo Italiano Trapianto di Midollo Osseo, Cellule Staminale Ematopoietiche (CSE) e Terapia Cellulare; Italian Bone Marrow Donor Registry. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation. Blood. 2009 Aug 13; 114(7):1437-44. PubMed

3.Zino E, Frumento G, Marktel S, Sormani MP, Ficara F, Di Terlizzi S, Parodi AM, Sergeant R, Martinetti M, Bontadini A, Bonifazi F, Lisini D, Mazzi B, Rossini S, Servida P, Ciceri F, Bonini C, Lanino E, Bandini G, Locatelli F, Apperley J, Bacigalupo A, Ferrara GB, Bordignon C, Fleischhauer K. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. Blood. 2004 Feb 15; 103(4):1417-24. PubMed

4.Fleischhauer K, Locatelli F, Zecca M, Orofino MG, Giardini C, De Stefano P, Pession A, Iannone AM, Carcassi C, Zino E, La Nasa G. Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction.Blood. 2006 Apr 1; 107(7):2984-92. PubMed

5.Zino E, Vago L, Di Terlizzi S, Mazzi B, Zito L, Sironi E, Rossini S, Bonini C, Ciceri F, Roncarolo MG, Bordignon C, Fleischhauer K. Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2007 Sep; 13(9):1031-40. PubMed

6.Urlacher A, Dormoy A, Tongio MM. DP epitope mapping by using T-cell clones. Hum Immunol. 1992; 35:100-108. PubMed

7.Cesbron A, Moreau P, Milpied N, Harousseau JL,Muller JY, Bignon JD. Crucial role of the third and fourth hypervariable regions of HLA-DPB1 allelic sequences in the mixed lymphocyte reaction. Hum Immunol. 1992; 33:202-207. PubMed

8.Naruse TK, Nose Y, Kagiya M, et al. Cloned primed lymphocyte test cells recognize the fourth, fifth, and sixth hypervariable regions at amino acid positions 65-87 of the DPB1 molecule. Hum Immunol. 1995; 42:123-130. PubMed


1.Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993; 364: 33-9. PubMed

2.Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 1996; 384: 134-41. PubMed

3.Hennecke J, Carfi A, Wiley DC. Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J 2000; 19: 5611-24.

4.Risler JL, Delorme MO, Delacroix H, Henaut A. Amino acid substitutions in structurally related proteins. A pattern recognition approach. Determination of a new and efficient scoring matrix. J Mol Biol 1988; 204: 1019-29. PubMed

5.Saper MA, Bjorkman, PJ, Wiley DC. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 resolution. J Mol Biol 1991; 219: 277-319. PubMed

6.Sayle RA, Milner-White EJ. RASMOL: biomolecular graphics for all. Trends Biochem Sci. 1995; 20: 374. PubMed

7.Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, Strominger JL, Wiley DC. Crystal structure of the human class II MHC protein HLA-DR1 complex with an influenza virus peptide. Nature 1994; 368: 215-21. PubMed

PDB Files

1.Madden, DR, Garboczi, DN, Wiley, DC. Human class I histocompatibility antigen (HLA-A*0201) complex with a decameric peptide from Hepatitis B nucleocapsid protein (residues 18-27). MMDB: 1178 ; PDB: 1HHH : 30-Jun-93. PubMed

2.Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, Strominger JL, Wiley DC. HLA-DR1 (DRA, DRB1*0101) Human class II histocompatibility protein (extracellular domain) complexed with antigenic peptide. MMDB: 764 ; PDB: 1DLH. PubMed